Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5806384 | 0.86 | NTRK1 (0.55) | KMT2AMAPTNTRK1ALDH1A1HTT | |
| SCHEMBL5804750 | 0.85 | ALDH1A1 (0.53) | KMT2AMAPTNTRK1ALDH1A1HTT | |
| SCHEMBL5806826 | 0.85 | MAPT (0.49) | KMT2AMAPTPTGS2NTRK1ALDH1A1 | |
| SCHEMBL5804612 | 0.83 | HSD11B1 (0.47) | KMT2ANOTUMALDH1A1LMNA | |
| SCHEMBL6413900 | 0.79 | KMT2A (0.54) | KMT2AMAPTNOTUMNTRK1ALDH1A1 | |
| SCHEMBL5808049 | 0.78 | NAPRT (0.45) | KMT2ANTRK1ALDH1A1HTTPOLB | |
| SCHEMBL3072718 | 0.78 | NR3C2 (0.48) | KMT2AMAPTNOTUMPTGS2NTRK1 | |
| SCHEMBL5807865 | 0.77 | PTGS1 (0.52) | KMT2AMAPTNOTUMPTGS2P2RX7 | |
| SCHEMBL31522204 | 0.76 | KMT2A (0.53) | KMT2AMAPTNOTUMNTRK1ALDH1A1 | |
| SCHEMBL15428579 | 0.75 | KMT2A (0.54) | KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | disclosed |
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | disclosed |