Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | YAP1 | P46937 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036608 | 0.79 | ATM (0.51) | ATMTSHRALOX15P2RX7MEN1 | |
| SCHEMBL5671946 | 0.77 | CNR1 (0.47) | ATMTSHRALOX15MEN1KMT2A | |
| SCHEMBL2792102 | 0.77 | P2RX7 (0.52) | ATMTSHRALOX15P2RX7YAP1 | |
| SCHEMBL23849296 | 0.77 | TSHR (0.51) | ATMTSHRALOX15TACR1KDM4E | |
| SCHEMBL5674705 | 0.76 | PKM (0.53) | MEN1KMT2AHDAC1HDAC2CNR1 | |
| SCHEMBL2185224 | 0.76 | KDM1A (0.46) | ATMTSHRALOX15MEN1KMT2A | |
| SCHEMBL4634595 | 0.76 | KDM1A (0.46) | ATMTSHRALOX15MEN1KMT2A | |
| SCHEMBL14357682 | 0.76 | KDM1A (0.48) | ATMTSHRALOX15MEN1KMT2A | |
| SCHEMBL5672765 | 0.76 | KDM1A (0.48) | ATMTSHRALOX15MEN1KMT2A | |
| SCHEMBL4634695 | 0.76 | HDAC2 (0.48) | ATMTSHRALOX15MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006086609-A2 | INHIBITORS OF TRYPTASE | AXYS PHARMACEUTICALS, INC. (US) | 2006-08-17 | — | — | WO | disclosed |