SCHEMBL5808159

SCHEMBL5808159

O=C(NO)c1ccc(/C=C(/CNc2cnc3ccc(CN4CCCC4)cc3c2)COc2cccc3ccccc23)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX3 P56373 2/20 0.58
HDAC6 Q9UBN7 9/20 0.47
HDAC1 Q13547 5/20 0.43
HDAC8 Q9BY41 4/20 0.43
HDAC3 O15379 3/20 0.43
HDAC2 Q92769 3/20 0.43
HDAC10 Q969S8 3/20 0.43
HDAC4 P56524 3/20 0.43
HDAC7 Q8WUI4 2/20 0.43
HDAC11 Q96DB2 2/20 0.43
HDAC9 Q9UKV0 2/20 0.43
HDAC5 Q9UQL6 2/20 0.43
HTR2C P28335 4/20 0.40
MCHR1 Q99705 4/20 0.40
TRPV1 Q8NER1 2/20 0.38
BDKRB1 P46663 1/20 0.38
NCOR2 Q9Y618 1/20 0.37
NPC1 O15118 1/20 0.37
LMNA P02545 1/20 0.37
POLB P06746 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5808165 1.00 P2RX3 (0.58) P2RX3HDAC6HDAC1HDAC8HDAC3
SCHEMBL5796315 0.94 P2RX3 (0.56) P2RX3HDAC6HDAC1HDAC8HDAC3
SCHEMBL5796309 0.94 P2RX3 (0.56) P2RX3HDAC6HDAC1HDAC8HDAC3
SCHEMBL5811096 0.93 P2RX3 (0.50) P2RX3HDAC6HTR2CMCHR1TRPV1
SCHEMBL5812325 0.93 P2RX3 (0.50) P2RX3HDAC6HTR2CMCHR1TRPV1
SCHEMBL5812294 0.91 P2RX3 (0.47) P2RX3HDAC6HTR2CMCHR1TRPV1
SCHEMBL5812289 0.91 P2RX3 (0.47) P2RX3HDAC6HTR2CMCHR1TRPV1
SCHEMBL5806985 0.87 P2RX3 (0.49) P2RX3HDAC6HDAC1HDAC8HDAC3
SCHEMBL5799137 0.86 HDAC6 (0.57) P2RX3HDAC6HDAC1HDAC8HDAC3
SCHEMBL5799135 0.86 HDAC6 (0.57) P2RX3HDAC6HDAC1HDAC8HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006025683-A1 ARYLAMINOMETHYL PROPENYL BENZHYDROXYAMID DERIVATIVES WITH INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND METHOD FOR THE PREPARATION THEREOF KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2006-03-09 WO claimed
WO-2006025683-A1 ARYLAMINOMETHYL PROPENYL BENZHYDROXYAMID DERIVATIVES WITH INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND METHOD FOR THE PREPARATION THEREOF KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2006-03-09 WO disclosed