Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.77 |
| ▸ | ICMT | O60725 | 13/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | FNTA | P49354 | 1/20 | 0.47 |
| ▸ | FNTB | P49356 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12848201 | 0.88 | MAPT (0.60) | MAPTALDH1A1ICMTMEN1TRPA1 | |
| SCHEMBL5420607 | 0.87 | MAPT (0.59) | MAPTALDH1A1ICMTMEN1TRPA1 | |
| SCHEMBL2871985 | 0.87 | MAPT (0.62) | MAPTALDH1A1ICMTMEN1TRPA1 | |
| SCHEMBL5420609 | 0.87 | MAPT (0.59) | MAPTALDH1A1ICMTMEN1TRPA1 | |
| SCHEMBL2871986 | 0.87 | MAPT (0.62) | MAPTALDH1A1ICMTMEN1TRPA1 | |
| SCHEMBL1648108 | 0.87 | MAPT (1.00) | MAPTALDH1A1ICMTMEN1TRPA1 | |
| SCHEMBL1648111 | 0.87 | MAPT (1.00) | MAPTALDH1A1ICMTMEN1TRPA1 | |
| SCHEMBL5274733 | 0.87 | MAPT (1.00) | MAPTALDH1A1ICMTMEN1TRPA1 | |
| SCHEMBL4024890 | 0.87 | MAPT (1.00) | MAPTALDH1A1ICMTMEN1TRPA1 | |
| SCHEMBL664393 | 0.87 | MAPT (1.00) | MAPTALDH1A1ICMTMEN1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006102126-A2 | INHIBITORS OF ISOPRENYLCYSTEINE CARBOXYL METHYLTRANSFERASE | DUKE UNIVERSITY (US) | 2006-09-28 | — | — | WO | disclosed |
| US-5571687-A | TREATING CELLS WITH SPECIFIED COMPOUNDS TO EFFECT EXPRESSION OF MEMBRANE TRANSPORTER | DUKE UNIVERSITY (US) | 1996-11-05 | — | — | US | disclosed |
| EP-0527896-A4 | SUBSTRATES AND INHIBITORS FOR PRENYL CYSTEINE METHYLTRANSFERASE ENZYMES | — | 1993-10-06 | — | — | EP | disclosed |
| EP-0527896-A1 | SUBSTRATES AND INHIBITORS FOR PRENYL CYSTEINE METHYLTRANSFERASE ENZYMES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1993-02-24 | — | — | EP | disclosed |
| WO-1991017261-A1 | SUBSTRATES AND INHIBITORS FOR PRENYL CYSTEINE METHYLTRANSFERASE ENZYMES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-11-14 | — | — | WO | disclosed |
| US-5043268-A | Quantitative, qualitative analysis | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-08-27 | — | — | US | disclosed |