Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | GABRP | O00591 | 1/20 | 0.50 |
| ▸ | GABRD | O14764 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.50 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.50 |
| ▸ | GABRE | P78334 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.50 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.50 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.50 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.50 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5808330 | 0.91 | POLB (0.61) | POLBTSHRGABRPGABRDGABRA1 | |
| SCHEMBL11291275 | 0.85 | HDAC8 (0.55) | POLBTSHRHDAC8HDAC6EPHX1 | |
| SCHEMBL16827095 | 0.81 | POLB (0.47) | POLBTSHRGABRPGABRDGABRA1 | |
| SCHEMBL3224577 | 0.80 | POLB (0.50) | POLBTSHRGABRPGABRDGABRA1 | |
| SCHEMBL13746134 | 0.78 | POLB (0.77) | POLBTSHRGABRPGABRDGABRA1 | |
| SCHEMBL7056987 | 0.78 | HDAC8 (0.67) | POLBTSHRHDAC8HDAC6EPHX1 | |
| SCHEMBL4693634 | 0.76 | HDAC8 (0.58) | POLBTSHRGABRPGABRDGABRA1 | |
| SCHEMBL9493161 | 0.75 | POLB (0.46) | POLBTSHRGABRPGABRDGABRA1 | |
| SCHEMBL31170413 | 0.75 | POLB (0.46) | POLBTSHRGABRPGABRDGABRA1 | |
| SCHEMBL6135434 | 0.75 | POLB (0.46) | POLBTSHRGABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006130426-A2 | MODULATORS OF CCR-5 ACTIVITY | KEMIA, INC. (US) | 2006-12-07 | — | — | WO | claimed |
| WO-2006130426-A2 | MODULATORS OF CCR-5 ACTIVITY | KEMIA, INC. (US) | 2006-12-07 | — | — | WO | disclosed |