SCHEMBL580867

SCHEMBL580867

COc1c(O)c(O)cc2c1oc1cc(C)oc(=O)c12

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 6/20 0.61
KMT2A Q03164 6/20 0.61
KDM4E B2RXH2 5/20 0.61
MAPT P10636 5/20 0.61
RECQL P46063 5/20 0.61
BLM P54132 4/20 0.61
HPGD P15428 3/20 0.61
CYP3A4 P08684 3/20 0.61
PKM P14618 3/20 0.61
HSD17B10 Q99714 3/20 0.61
ALOX12 P18054 2/20 0.61
THRB P10828 2/20 0.61
ALDH1A1 P00352 2/20 0.60
TP53 P04637 1/20 0.60
MAOA P21397 3/20 0.48
KLK7 P49862 1/20 0.48
KLK5 Q9Y337 1/20 0.48
APEX1 P27695 2/20 0.48
TDP1 Q9NUW8 2/20 0.48
PTGS1 P23219 6/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10135381 0.89 KDM4E (0.52) MEN1KMT2AKDM4EMAPTRECQL
SCHEMBL10181450 0.84 PTGS1 (0.51) MEN1KMT2AKDM4EMAPTRECQL
SCHEMBL581188 0.83 KDM4E (0.59) MEN1KMT2AKDM4EMAPTRECQL
SCHEMBL10181747 0.82 MGAM (0.57) MEN1KMT2AKDM4EMAPTRECQL
SCHEMBL16167899 0.81 PGAM1 (0.45) MEN1KMT2AKDM4EMAPTRECQL
SCHEMBL580976 0.81 KDM4E (0.44) MEN1KMT2AKDM4EMAPTRECQL
SCHEMBL10182055 0.81 MEN1 (0.46) MEN1KMT2AKDM4EMAPTRECQL
SCHEMBL10182478 0.81 MEN1 (0.45) MEN1KMT2AKDM4EMAPTRECQL
SCHEMBL10182662 0.76 ESR1 (0.40) MEN1KMT2AKDM4EMAPTRECQL
SCHEMBL10135386 0.76 KDM4E (0.50) MEN1KMT2AKDM4EMAPTRECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2121141-B1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS BASF SE (DE) 2012-02-15 EP claimed
US-20100330009-A1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS CIBA CORPORATION (US) 2010-12-30 US claimed
EP-2121141-A1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS BASF SE (DE) 2009-11-25 EP claimed
WO-2008110465-A1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS BASF SE (CH) 2008-09-18 WO claimed
EP-2464739-B1 METHODS IN CELL CULTURES, AND RELATED INVENTIONS, EMPLOYING CERTAIN ADDITIVES BASF SE (DE) 2016-01-13 EP disclosed
US-8859235-B2 Methods in cell cultures, and related inventions, employing certain additives BASF SE (DE) 2014-10-14 US disclosed
US-8383088-B2 Coumestan-like antioxidants and UV absorbants BASF SE (DE) 2013-02-26 US disclosed
US-8383088-B2 Coumestan-like antioxidants and UV absorbants BASF SE (DE) 2013-02-26 US disclosed
US-8383088-B2 Coumestan-like antioxidants and UV absorbants BASF SE (DE) 2013-02-26 US disclosed
EP-2121141-B1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS BASF SE (DE) 2012-02-15 EP disclosed
EP-2121141-B1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS BASF SE (DE) 2012-02-15 EP disclosed
WO-2011018472-A2 METHODS IN CELL CULTURES, AND RELATED INVENTIONS, EMPLOYING CERTAIN ADDITIVES BASF SE (DE) 2011-02-17 WO disclosed
US-20100330009-A1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS CIBA CORPORATION (US) 2010-12-30 US disclosed
US-20100330009-A1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS CIBA CORPORATION (US) 2010-12-30 US disclosed
US-20100330009-A1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS CIBA CORPORATION (US) 2010-12-30 US disclosed
EP-2121141-A1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS BASF SE (DE) 2009-11-25 EP disclosed
WO-2008110465-A1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS BASF SE (CH) 2008-09-18 WO disclosed
WO-2008110465-A1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS BASF SE (CH) 2008-09-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100330009-A1 COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS TYR, NQO1, SIRT3 MEN1 3538/4885KMT2A 3660/4885KDM4E 1307/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.