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Sugi Predict / Targets / PGAM1

PGAM1

Phosphoglycerate mutase 1 · P18669 · PGAM1 on Sugi Atlas →

9,485 patent compounds predicted against PGAM1, 6,096 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1506809 SCHEMBL1506809 0.48 9/20
SCHEMBL1506814 SCHEMBL1506814 0.73 8/20
Alizarin Red Alizarin Red (SCHEMBL728494) 1.00 7/20
Alizarin Red Alizarin Red (SCHEMBL1203855) 1.00 7/20
Alizarin Red Alizarin Red (SCHEMBL433811) 0.97 7/20
Alizarin Red Alizarin Red (SCHEMBL728495) 0.97 7/20
SCHEMBL436684 SCHEMBL436684 0.57 7/20
SCHEMBL555230 SCHEMBL555230 0.64 6/20
Rubiadin Rubiadin (SCHEMBL1426928) 0.54 6/20
SCHEMBL2781130 SCHEMBL2781130 0.51 6/20
SCHEMBL387223 SCHEMBL387223 0.48 6/20
SCHEMBL2870441 SCHEMBL2870441 0.68 5/20
SCHEMBL2855936 SCHEMBL2855936 0.61 5/20
SCHEMBL705681 SCHEMBL705681 0.51 5/20
SCHEMBL419737 SCHEMBL419737 0.66 4/20
SCHEMBL2163644 SCHEMBL2163644 0.46 4/20
SCHEMBL2905863 SCHEMBL2905863 0.43 4/20
SCHEMBL2053786 SCHEMBL2053786 0.72 3/20
SCHEMBL2853522 SCHEMBL2853522 0.65 3/20
SCHEMBL3079411 SCHEMBL3079411 0.64 3/20

Clinical trials — most relevant to PGAM1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Glutamate for Metabolic Intervention in Coronary Surgery PHASE3COMPLETED
Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency: PHASE3ACTIVE_NOT_RECRUITING
The Effect of Triheptanoin on Fatty Acid Oxidation and Exercise Tolerance in Patients With Glycogenoses PHASE2COMPLETED
Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype PHASE2ACTIVE_NOT_RECRUITING
Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease PHASE2RECRUITING
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
Metformin Plus/Minus Fasting Mimicking Diet to Target the Metabolic Vulnerabilities of LKB1-inactive Lung Adenocarcinoma PHASE2UNKNOWN
GDF-15 as a Biomarker for Mitochondrial Disease nanCOMPLETED
Biomarkers in Exhaled Breath Condensates in Acute Lung Injury: Early Detection and Outcome Predictors nanUNKNOWN
13C Pyruvate DNP MR Spectroscopy for Lymphoma Treatment Response Assessment nanUNKNOWN
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia nanRECRUITING
Role of p53 Gene in Metabolism Regulation in Patients With Li-Fraumeni Syndrome nanCOMPLETED
METabolic PROFILE of Hepatocarcinoma and Pancreatic Tumors nanRECRUITING
Identification of a New Blood Biomarker for the Diagnosis and Prognosis of Liposarcomas nanRECRUITING
Natural History and Advanced Genetic Study of Pyruvate Dehydrogenase Complex Deficiencies nanRECRUITING
Genetic and Family Studies of Inherited Muscle Diseases nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML) nanCOMPLETED
McArdle Disease Treatment by Ketogenic Diet nanCOMPLETED
Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype (SASP) nanNOT_YET_RECRUITING
GSD VI and GSD IX Natural History nanRECRUITING
Mitochondrial Dysfunction in Phelan-McDermid Syndrome nanCOMPLETED
Role of Metabolic Enzymes in Non-Melanoma Skin Cancer nanCOMPLETED
Assessment of Energy Metabolism in Metabolic Myopathies nanCOMPLETED
Genetic Studies of Lysosomal Storage Disorders nanENROLLING_BY_INVITATION
Tolerability and Efficacy of L-Serine in Patients With GRIN-related Encephalopathy nanUNKNOWN
Study of Metabolic Changes in the Transformation Malignant Precancerous Skin Lesions nanCOMPLETED
MyRareDiet A Novel Diet Tracking Tool nanNOT_YET_RECRUITING
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Implementing Preemptive Pharmacogenomic Testing for Colorectal Cancer Patients in a Community Oncology Clinic nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a PGAM1 binder may also engage these)

ProteinNameSimilarity
P25113 — 1.000 P25113 →
Q9DBJ1 — 1.000 Q9DBJ1 →
Q3SZ62 — 0.999 Q3SZ62 →
Q5RFB8 — 0.998 Q5RFB8 →
Q32KV0 — 0.996 Q32KV0 →
Q5ZLN1 — 0.994 Q5ZLN1 →
P15259 — 0.993 P15259 →
O70250 — 0.993 O70250 →
Q8N0Y7 — 0.990 Q8N0Y7 →
P16290 — 0.989 P16290 →
Q8MKE8 — 0.987 Q8MKE8 →
Q82GB8 — 0.985 Q82GB8 →
A1WBJ3 — 0.985 A1WBJ3 →
Q8KFC8 — 0.983 Q8KFC8 →
B3QPN8 — 0.982 B3QPN8 →
Q01YD0 — 0.981 Q01YD0 →
Q0BBK5 — 0.981 Q0BBK5 →
A1VKR6 — 0.980 A1VKR6 →
Q2T1H5 — 0.980 Q2T1H5 →
Q5P7N4 — 0.980 Q5P7N4 →
B2VBS6 — 0.980 B2VBS6 →
A4SDM0 — 0.979 A4SDM0 →
B4S616 — 0.979 B4S616 →
A4JI45 — 0.978 A4JI45 →
C5CWV9 — 0.978 C5CWV9 →
A3N5B0 — 0.977 A3N5B0 →
Q21YW0 — 0.977 Q21YW0 →
B1YNA6 — 0.977 B1YNA6 →
Q39CN6 — 0.976 Q39CN6 →
A1TTW5 — 0.976 A1TTW5 →