Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 14/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | FPR1 | P21462 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | RORA | P35398 | 2/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.50 |
| ▸ | RORB | Q92753 | 2/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8295771 | 0.81 | HSD17B10 (0.53) | RORCALDH1A1FPR1HSD17B10RORA | |
| SCHEMBL5446559 | 0.80 | CNR2 (0.51) | RORCHSD17B10AOC3HSP90AA1CA1 | |
| SCHEMBL4569291 | 0.74 | HSP90AA1 (0.52) | RORCALDH1A1FPR1HSD17B10RORA | |
| SCHEMBL5966740 | 0.73 | HSP90AA1 (0.50) | RORCALDH1A1FPR1HSD17B10RORA | |
| SCHEMBL11150349 | 0.71 | HSP90AA1 (0.49) | RORCALDH1A1FPR1HSD17B10RORA | |
| SCHEMBL3174757 | 0.71 | HSP90AA1 (0.57) | ALDH1A1HSD17B10AOC3HSP90AA1CA1 | |
| SCHEMBL15054985 | 0.71 | RORC (0.69) | RORCRORANR1H2NR1H3RORB | |
| SCHEMBL28846689 | 0.71 | RORC (0.65) | RORCRORANR1H2NR1H3RORB | |
| SCHEMBL10900809 | 0.71 | HSP90AA1 (0.52) | RORCHSD17B10HSP90AA1CA1CA2 | |
| SCHEMBL15055740 | 0.70 | RORC (0.64) | RORCALDH1A1FPR1HSD17B10RORA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | claimed |