SCHEMBL5809059

SCHEMBL5809059

C#Cc1ccc(C(=O)C(=O)Nc2cc(C(C)(C)C)cc(NS(C)(=O)=O)c2OC)c2ccccc12

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 11/20 0.68
SCARB1 Q8WTV0 9/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1600035 0.87 SCARB1 (0.74) MAPK14SCARB1
SCHEMBL4949130 0.86 MAPK14 (0.71) MAPK14SCARB1
SCHEMBL5820136 0.83 SCARB1 (0.77) MAPK14SCARB1
SCHEMBL1600378 0.81 SCARB1 (0.78) MAPK14SCARB1
SCHEMBL12669833 0.81 SCARB1 (0.76) MAPK14SCARB1
SCHEMBL1600447 0.81 MAPK14 (0.73) MAPK14SCARB1
SCHEMBL5312427 0.81 MAPK14 (1.00) MAPK14SCARB1
SCHEMBL4416952 0.80 MAPK14 (0.65) MAPK14SCARB1
SCHEMBL4947564 0.80 SCARB1 (0.74) MAPK14SCARB1
SCHEMBL1598932 0.80 MAPK14 (0.62) MAPK14SCARB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006091862-A2 CYTOKINE INHIBITORS AND THEIR USE IN THERAPY KEMIA, INC. (US) 2006-08-31 WO disclosed