Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 9/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL582517 | 0.96 | TACR1 (0.42) | TACR1ALDH1A1USP2LMNAMAPK1 | |
| SCHEMBL582518 | 0.96 | TACR1 (0.42) | TACR1ALDH1A1USP2LMNAMAPK1 | |
| SCHEMBL581119 | 0.90 | NOTUM (0.43) | TACR1NOTUMSIGMAR1 | |
| SCHEMBL599010 | 0.89 | CYP11B1 (0.39) | TACR1ALDH1A1USP2LMNAMAPK1 | |
| SCHEMBL581169 | 0.89 | CYP11B1 (0.39) | TACR1ALDH1A1USP2LMNAMAPK1 | |
| SCHEMBL581644 | 0.89 | CYP11B1 (0.39) | TACR1ALDH1A1USP2LMNAMAPK1 | |
| SCHEMBL581795 | 0.89 | ALDH1A1 (0.47) | ALDH1A1NOTUMUSP2LMNAMAPK1 | |
| SCHEMBL581796 | 0.89 | ALDH1A1 (0.47) | ALDH1A1NOTUMUSP2LMNAMAPK1 | |
| SCHEMBL581727 | 0.88 | NOTUM (0.38) | ALDH1A1NOTUMMAPK1 | |
| SCHEMBL581726 | 0.88 | NOTUM (0.38) | ALDH1A1NOTUMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |