Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | MTOR | P42345 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | CASP6 | P55212 | 2/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4907770 | 0.79 | HDAC8 (0.52) | GAAMAPTNPC1MTORRAB9A | |
| SCHEMBL4907784 | 0.79 | HDAC8 (0.52) | GAAMAPTNPC1MTORRAB9A | |
| SCHEMBL4907788 | 0.79 | HDAC8 (0.52) | GAAMAPTNPC1MTORRAB9A | |
| SCHEMBL4751701 | 0.78 | MAPT (0.79) | GAAMAPTKDM4ENPC1MTOR | |
| SCHEMBL4751703 | 0.78 | MAPT (0.79) | GAAMAPTKDM4ENPC1MTOR | |
| SCHEMBL10281920 | 0.74 | KDM4E (0.67) | GAAMAPTKDM4ENPC1MTOR | |
| SCHEMBL683780 | 0.73 | KDM1A (0.60) | GAAMAPTMTORHTTRAB9A | |
| SCHEMBL10143899 | 0.72 | ESRRG (0.68) | GAAMAPTKDM4ENPC1MTOR | |
| SCHEMBL684551 | 0.72 | KDM1A (0.70) | GAAMAPTKDM4ENPC1RAB9A | |
| SCHEMBL6635457 | 0.71 | NPC1 (0.77) | GAAMAPTNPC1MTORRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006136008-A1 | SALICYLIC ACID HYDRAZONES AS INHIBITORS OF THE ERK MAPKINASE PATHWAY AND FOR THE TREATMENT OF CANCER | UNIVERSITY HEALTH NETWORK (CA) | 2006-12-28 | — | — | WO | claimed |
| WO-2006136008-A1 | SALICYLIC ACID HYDRAZONES AS INHIBITORS OF THE ERK MAPKINASE PATHWAY AND FOR THE TREATMENT OF CANCER | UNIVERSITY HEALTH NETWORK (CA) | 2006-12-28 | — | — | WO | disclosed |