Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 3/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.38 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5128670 | 0.95 | SMN1; SMN2 (0.44) | SMN1; SMN2CHRM4PRKCITNFNOD1 | |
| SCHEMBL5122410 | 0.91 | SMN1; SMN2 (0.42) | SMN1; SMN2CHRM4PRKCIPDE5AADORA2A | |
| SCHEMBL5123241 | 0.90 | CHRM4 (0.42) | SMN1; SMN2CHRM4TNFNOD1STAT1 | |
| SCHEMBL5808228 | 0.89 | POLB (0.44) | SMN1; SMN2CHRM4TNFNOD1STAT1 | |
| SCHEMBL5814772 | 0.88 | ADORA2A (0.48) | SMN1; SMN2CHRM4PRKCINPC1GAA | |
| SCHEMBL7174986 | 0.87 | ALDH1A1 (0.52) | SMN1; SMN2PRKCIMEN1KMT2ANPC1 | |
| SCHEMBL5130359 | 0.84 | ADORA2A (0.51) | SMN1; SMN2CHRM4PRKCIGAARXFP1 | |
| SCHEMBL5120980 | 0.84 | BCDIN3D (0.41) | CHRM4PDE5AADORA2ALIMK1LIMK2 | |
| SCHEMBL7515097 | 0.84 | ALDH1A1 (0.43) | SMN1; SMN2CHRM4PRKCIMEN1KMT2A | |
| SCHEMBL7509747 | 0.84 | MAPT (0.42) | SMN1; SMN2CHRM4PRKCIMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685136-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005047292-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 2005-05-26 | — | — | WO | disclosed |