Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.61 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.61 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.61 |
| ▸ | PPARG | P37231 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | PTGES | O14684 | 1/20 | 0.61 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.61 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | ALB | P02768 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.61 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.61 |
| ▸ | AR | P10275 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL10910165 | 0.99 | PTGS2 (0.60) | PTGS2PTGS1AKR1C3AKR1C2PPARG | |
| SCHEMBL11828310 | 0.99 | PTGS2 (0.60) | PTGS2PTGS1AKR1C3AKR1C2PPARG | |
| SCHEMBL11074409 | 0.94 | PTGS2 (0.56) | PTGS2PTGS1AKR1C3AKR1C2PPARG | |
| SCHEMBL10909068 | 0.91 | LMNA (0.59) | PTGS2PTGS1AKR1C3AKR1C2PPARG | |
| SCHEMBL10849678 | 0.87 | PTGS2 (0.58) | PTGS2PTGS1AKR1C3AKR1C2PPARG | |
| SCHEMBL11615782 | 0.86 | PTGS2 (0.59) | PTGS2PTGS1AKR1C3AKR1C2PPARG | |
| SCHEMBL11621747 | 0.85 | PTGS2 (0.64) | PTGS2PTGS1AKR1C3AKR1C2PPARG | |
| SCHEMBL28817659 | 0.85 | PTGS2 (0.64) | PTGS2PTGS1AKR1C3AKR1C2PPARG | |
| SCHEMBL2739295 | 0.84 | PTGS2 (0.66) | PTGS2PTGS1AKR1C3AKR1C2PPARG | |
| SCHEMBL31612394 | 0.84 | PTGS2 (0.63) | PTGS2PTGS1AKR1C3AKR1C2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0087656-B1 | PROCESS FOR THE PREPARATION OF 1-(4-CHLORBENZOYL)-5-METHOXY-2-METHYL-3-INDOLYLACETOXY-ACETIC ACID | Troponwerke GmbH & Co. KG (DE) | 1986-05-07 | — | — | EP | claimed |
| EP-0087654-B1 | PROCESS FOR THE PREPARATION OF 1-(4-CHLORBENZOYL)-5-METHOXY-2-METHYL-3-INDOLYLACETOXY-ACETIC ACID | Troponwerke GmbH & Co. KG (DE) | 1986-04-30 | — | — | EP | claimed |
| US-4503237-A | Method for the production of acemetacin | SIEGFRIED AKTIENGESELLSCHAFT (CH) | 1985-03-05 | — | — | US | claimed |
| US-3966956-A | [1-(P-Chlorobenzoyl)-5-methoxy-2-methyl-3-indole]acetoxyacetic acid and salts in treating inflammation | TROPONWERKE DINKLAGE & COMPANY (DT) | 1976-06-29 | — | — | US | claimed |
| CN-107320732-B | High penetration composition and application thereof | 于崇曦 | 2021-09-07 | — | — | CN | disclosed |
| CN-108191846-B | High penetration composition and application thereof | 于崇曦 | 2021-08-20 | — | — | CN | disclosed |
| CN-111808011-A | High penetration composition and application thereof | 于崇曦 | 2020-10-23 | — | — | CN | disclosed |
| WO-2006099677-A1 | METAL COMPLEXES | MEDICAL THERAPIES LIMITED (AU) | 2006-09-28 | — | — | WO | disclosed |
| EP-0126942-B1 | PREPARATION PROCESS OF ACEMETACIN | Troponwerke GmbH & Co. KG (DE) | 1987-09-30 | — | — | EP | disclosed |
| US-4603210-A | Preparation process of acemetacin | TROPONWERKE GMBH & CO. KG. (DE) | 1986-07-29 | — | — | US | disclosed |
| US-4585880-A | Process for the preparation of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetoxyacetic acid | TROPONWERKE GMBH & CO. KG (DE) | 1986-04-29 | — | — | US | disclosed |
| US-4585880-A | Process for the preparation of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetoxyacetic acid | TROPONWERKE GMBH & CO. KG (DE) | 1986-04-29 | — | — | US | disclosed |
| US-4459415-A | Process for the preparation of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetoxyacetic acid | TROPONWERKE GMBH & CO. KG (DE) | 1984-07-10 | — | — | US | disclosed |
| US-4459415-A | Process for the preparation of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetoxyacetic acid | TROPONWERKE GMBH & CO. KG (DE) | 1984-07-10 | — | — | US | disclosed |
| EP-0088252-A1 | Process for the preparation of 1-(4-chlorbenzoyl)-5-methoxy-2-methyl-3-indolacetoxy-acetic acid | Troponwerke GmbH & Co. KG (DE) | 1983-09-14 | — | — | EP | disclosed |
| EP-0087657-A1 | Process for the preparation of 1-(4-chlorbenzoyl)-5-methoxy-2-methyl-3-indolylacetoxy-acetic acid | Troponwerke GmbH & Co. KG (DE) | 1983-09-07 | — | — | EP | disclosed |
| EP-0027956-A1 | Process for preparing (1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indole) acetoxy acetic acid | Troponwerke GmbH & Co. KG (DE) | 1981-05-06 | — | — | EP | disclosed |
| US-4104278-A | Process for the production of compounds with antiphlogistic activity | TROPONWERKE DINKLAGE & CO. (DE) | 1978-08-01 | — | — | US | disclosed |
| US-3966956-A | [1-(P-Chlorobenzoyl)-5-methoxy-2-methyl-3-indole]acetoxyacetic acid and salts in treating inflammation | TROPONWERKE DINKLAGE & COMPANY (DT) | 1976-06-29 | — | — | US | disclosed |
| US-3966956-A | [1-(P-Chlorobenzoyl)-5-methoxy-2-methyl-3-indole]acetoxyacetic acid and salts in treating inflammation | TROPONWERKE DINKLAGE & COMPANY (DT) | 1976-06-29 | — | — | US | disclosed |