Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | JAK1 | P23458 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | PLAU | P00749 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | FABP6 | P51161 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | PLG | P00747 | 1/20 | 0.50 |
| ▸ | PLAT | P00750 | 1/20 | 0.50 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.50 |
| ▸ | KLK1 | P06870 | 1/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11212341 | 0.86 | NPC1 (0.59) | JAK2JAK1RAB9ANPC1ALDH1A1 | |
| SCHEMBL4247281 | 0.83 | NPC1 (0.65) | RAB9ANPC1MEN1KMT2AKDM4E | |
| SCHEMBL23830419 | 0.83 | CHEK2 (0.65) | RAB9ANPC1LMNAMAPTPOLB | |
| SCHEMBL3239662 | 0.81 | MMP9 (0.54) | MEN1KMT2AMMP9ALOX15BLM | |
| SCHEMBL416899 | 0.80 | ABL1 (0.78) | RAB9AALDH1A1LMNAPOLBHPGD | |
| SCHEMBL14381542 | 0.80 | MMP2 (0.77) | RAB9ANPC1ALDH1A1MAPTPOLB | |
| SCHEMBL1870891 | 0.79 | FABP6 (0.55) | RAB9ANPC1ALDH1A1HPGDPLAU | |
| SCHEMBL4239702 | 0.79 | NPC1 (0.65) | RAB9ANPC1LMNAMAPTPOLB | |
| SCHEMBL23812465 | 0.79 | MAPT (0.59) | RAB9ANPC1ALDH1A1MAPTPOLB | |
| Bromide SCHEMBL16324631 | 0.79 | ABL1 (0.76) | RAB9AALDH1A1LMNAPOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664021-A1 | N-SUBSTITUTED BENZIMIDAZOLYL C-KIT INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005021531-A1 | N-SUBSTITUTED BENZIMIDAZOLYL C-KIT INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2005-03-10 | — | — | WO | disclosed |