Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | DDO | Q99489 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11007640 | 0.87 | KMT2A (0.46) | RPA1MCL1KDM4ETSHRHPGD | |
| SCHEMBL5810858 | 0.80 | KDM4E (0.42) | RPA1MCL1KDM4ETSHRHPGD | |
| SCHEMBL27523818 | 0.79 | MCL1 (0.65) | RPA1MCL1KDM4ETSHRHPGD | |
| SCHEMBL2483507 | 0.76 | KDM4E (0.50) | KDM4EHPGDKMT2ADAODDO | |
| SCHEMBL4649345 | 0.76 | PARP4 (0.37) | KDM4EHPGDMAPTGAADAO | |
| SCHEMBL10652877 | 0.76 | ALDH1A1 (0.48) | KDM4ETSHRHPGDLMNAKMT2A | |
| SCHEMBL11619748 | 0.74 | AHR (0.49) | RPA1MCL1KDM4ETSHRHPGD | |
| SCHEMBL18264142 | 0.74 | KDM5A (0.47) | KDM4ETSHRHPGDLMNAPOLB | |
| SCHEMBL10653175 | 0.74 | ALDH1A1 (0.41) | KDM4ETSHRHPGDLMNAPOLB | |
| SCHEMBL3985154 | 0.73 | KDM4E (0.74) | KDM4ELMNAKMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006089689-A1 | 2-QUINOLONE COMPOUNDS AS INHIBITORS OF PHOSPHODIESTERASES | GLAXO GROUP LIMITED (GB) | 2006-08-31 | — | — | WO | disclosed |