Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.37 |
| ▸ | LDHA | P00338 | 3/20 | 0.37 |
| ▸ | LDHB | P07195 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | DDO | Q99489 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8258156 | 0.87 | PARP4 (0.38) | PARP4LDHALDHBKDM4EHSD17B10 | |
| SCHEMBL4647324 | 0.82 | ALDH1A1 (0.51) | CYP3A4MAPTKDM4EGAAHPGD | |
| SCHEMBL4649252 | 0.81 | GABRG2 (0.38) | PARP4KDM4E | |
| SCHEMBL4801279 | 0.78 | KMT2A (0.39) | KDM4EHSD17B10GAATDP1 | |
| SCHEMBL5809605 | 0.76 | RPA1 (0.49) | MAPTKDM4EHSD17B10GAAHPGD | |
| SCHEMBL10648403 | 0.70 | ABCB1 (0.46) | MAPTKDM4EHSD17B10GAAGRIN2D | |
| SCHEMBL23600938 | 0.69 | CYP3A4 (0.50) | LDHALDHBCYP3A4MAPTKDM4E | |
| SCHEMBL31447231 | 0.68 | KMT2A (0.33) | LDHALDHBCYP3A4MAPTKDM4E | |
| SCHEMBL5820311 | 0.68 | LDHA (0.35) | LDHALDHBCYP3A4MAPTKDM4E | |
| SCHEMBL11379798 | 0.67 | KDM4E (0.60) | LDHALDHBMAPTKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960363-A2 | QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | Amgen, Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007070359-A2 | QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMGEN INC. (US) | 2007-06-21 | — | — | WO | disclosed |
| WO-2006089689-A1 | 2-QUINOLONE COMPOUNDS AS INHIBITORS OF PHOSPHODIESTERASES | GLAXO GROUP LIMITED (GB) | 2006-08-31 | — | — | WO | disclosed |
| WO-2006089689-A1 | 2-QUINOLONE COMPOUNDS AS INHIBITORS OF PHOSPHODIESTERASES | GLAXO GROUP LIMITED (GB) | 2006-08-31 | — | — | WO | disclosed |