Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 20/20 | 1.00 |
| ▸ | TUBB | P07437 | 20/20 | 1.00 |
| ▸ | TUBA3C | P0DPH7 | 20/20 | 1.00 |
| ▸ | TUBA1B | P68363 | 20/20 | 1.00 |
| ▸ | TUBA4A | P68366 | 20/20 | 1.00 |
| ▸ | TUBB4B | P68371 | 20/20 | 1.00 |
| ▸ | TUBB3 | Q13509 | 20/20 | 1.00 |
| ▸ | TUBB2A | Q13885 | 20/20 | 1.00 |
| ▸ | TUBB8 | Q3ZCM7 | 20/20 | 1.00 |
| ▸ | TUBA3E | Q6PEY2 | 20/20 | 1.00 |
| ▸ | TUBA1A | Q71U36 | 20/20 | 1.00 |
| ▸ | TUBA1C | Q9BQE3 | 20/20 | 1.00 |
| ▸ | TUBB6 | Q9BUF5 | 20/20 | 1.00 |
| ▸ | TUBB2B | Q9BVA1 | 20/20 | 1.00 |
| ▸ | TUBB1 | Q9H4B7 | 20/20 | 1.00 |
| ▸ | IDO1 | P14902 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28061063 | 0.81 | TUBB4A (0.67) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5812276 | 0.79 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5809417 | 0.79 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5807181 | 0.79 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5808034 | 0.79 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5811687 | 0.79 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5812015 | 0.79 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL2552819 | 0.77 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL28679306 | 0.77 | TUBB4A (0.62) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL11611676 | 0.76 | TUBB4A (0.60) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006041961-A1 | ARYLTHIOINDOLE TUBULIN POLYMERIZATION INHIBITORS AND METHODS OF TREATING OR PREVENTING CANCER USING SAME | GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTHAND HUMAN SERVICES (US) | 2006-04-20 | — | — | WO | disclosed |