Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 19/20 | 1.00 |
| ▸ | TUBB | P07437 | 19/20 | 1.00 |
| ▸ | TUBA3C | P0DPH7 | 19/20 | 1.00 |
| ▸ | TUBA1B | P68363 | 19/20 | 1.00 |
| ▸ | TUBA4A | P68366 | 19/20 | 1.00 |
| ▸ | TUBB4B | P68371 | 19/20 | 1.00 |
| ▸ | TUBB3 | Q13509 | 19/20 | 1.00 |
| ▸ | TUBB2A | Q13885 | 19/20 | 1.00 |
| ▸ | TUBB8 | Q3ZCM7 | 19/20 | 1.00 |
| ▸ | TUBA3E | Q6PEY2 | 19/20 | 1.00 |
| ▸ | TUBA1A | Q71U36 | 19/20 | 1.00 |
| ▸ | TUBA1C | Q9BQE3 | 19/20 | 1.00 |
| ▸ | TUBB6 | Q9BUF5 | 19/20 | 1.00 |
| ▸ | TUBB2B | Q9BVA1 | 19/20 | 1.00 |
| ▸ | TUBB1 | Q9H4B7 | 19/20 | 1.00 |
| ▸ | IDO1 | P14902 | 2/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5808034 | 0.84 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5812276 | 0.84 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5809417 | 0.84 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5807181 | 0.84 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5811687 | 0.84 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL2552819 | 0.82 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL22802299 | 0.81 | IDO1 (0.71) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5811628 | 0.80 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5809696 | 0.79 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL22802281 | 0.78 | TUBB4A (0.63) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9944597-B2 | Polysubstituted pyrroles having microtubule-disrupting, cytotoxic and antitumor activities and methods of use thereof | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2018-04-17 | — | — | US | disclosed |
| US-20160297757-A1 | POLYSUBSTITUTED PYRROLES HAVING MICROTUBULE-DISRUPTING, CYTOTOXIC AND ANTITUMOR ACTIVITIES AND METHODS OF USE THEREOF | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SY STEM (US) | 2016-10-13 | — | — | US | disclosed |
| WO-2015039073-A1 | POLYSUBSTITUTED PYRROLES HAVING MICROTUBULE-DISRUPTING, CYTOTOXIC AND ANTITUMOR ACTIVITIES AND METHDS OF USE THEREOF | KELLOGG GLEN E (US) | 2015-03-19 | — | — | WO | disclosed |
| WO-2006041961-A1 | ARYLTHIOINDOLE TUBULIN POLYMERIZATION INHIBITORS AND METHODS OF TREATING OR PREVENTING CANCER USING SAME | GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTHAND HUMAN SERVICES (US) | 2006-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160297757-A1 | POLYSUBSTITUTED PYRROLES HAVING MICROTUBULE-DISRUPTING, CYTOTOXIC AND ANTITUMOR ACTIVITIES AND METHODS OF USE THEREOF | TUBB3, TUBB1, TUBB | TUBB4A 11/4885TUBB 3/4885TUBA3C 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.