SCHEMBL5810173

SCHEMBL5810173

O=c1ccn(I)c2ccccc12

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.39
MAPK1 P28482 1/20 0.39
HPGD P15428 1/20 0.38
P2RX4 Q99571 1/20 0.37
ERCC1 P07992 1/20 0.36
FEN1 P39748 1/20 0.36
ERCC4 Q92889 1/20 0.36
PAX8 Q06710 1/20 0.35
ALDH1A1 P00352 1/20 0.35
PGR P06401 4/20 0.35
NR3C1 P04150 3/20 0.35
NR3C2 P08235 3/20 0.35
GPR3 P46089 1/20 0.34
RORA P35398 1/20 0.33
RORC P51449 1/20 0.33
RORB Q92753 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2C19 P33261 1/20 0.33
CYP19A1 P11511 1/20 0.33
KDM4E B2RXH2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19810738 0.76 MAPK1 (0.40) SMN1; SMN2MAPK1HPGDP2RX4ERCC1
SCHEMBL8579432 0.76 MAPK1 (0.40) SMN1; SMN2MAPK1HPGDP2RX4ERCC1
SCHEMBL6667748 0.74 ERCC1 (0.44) SMN1; SMN2MAPK1HPGDP2RX4ERCC1
SCHEMBL29576413 0.74 ALDH1A1 (0.59) SMN1; SMN2MAPK1HPGDERCC1FEN1
SCHEMBL1537961 0.74 MAPK1 (0.39) SMN1; SMN2MAPK1HPGDP2RX4ERCC1
SCHEMBL1809581 0.74 ALDH1A1 (0.59) SMN1; SMN2MAPK1HPGDERCC1FEN1
SCHEMBL19810833 0.74 MAPK1 (0.39) SMN1; SMN2MAPK1HPGDP2RX4ERCC1
Hydrochloric Acid SCHEMBL29744398 0.72 ALDH1A1 (0.57) SMN1; SMN2MAPK1HPGDERCC1FEN1
SCHEMBL29350315 0.71 MAPK1 (0.37) SMN1; SMN2MAPK1HPGDP2RX4ERCC1
SCHEMBL7662776 0.71 COMT (0.49) SMN1; SMN2MAPK1HPGDPGRKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3885344-A2 PYRIMIDINE COMPOUNDS, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USES THEREOF InventisBio Co., Ltd. (CN) 2021-09-29 EP disclosed
WO-2017096045-A1 MULTIVALENT RAS BINDING COMPOUNDS KYRAS THERAPEUTICS, INC. (US) 2017-06-08 WO disclosed
EP-1644375-A2 FUSED-ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO Arena Pharmaceuticals, Inc. (US) 2006-04-12 EP disclosed
WO-2005007658-A2 FUSED-ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2005-01-27 WO disclosed
US-6248739-B1 DNA POLYMERASE INHIBITORS EFFECTIVE AGAINST HERPESVIRUSES PHARMACIA & UPJOHN COMPANY 2001-06-19 US disclosed