Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 8/20 | 0.65 |
| ▸ | TUBB | P07437 | 8/20 | 0.65 |
| ▸ | TUBA3C | P0DPH7 | 8/20 | 0.65 |
| ▸ | TUBA1B | P68363 | 8/20 | 0.65 |
| ▸ | TUBA4A | P68366 | 8/20 | 0.65 |
| ▸ | TUBB4B | P68371 | 8/20 | 0.65 |
| ▸ | TUBB3 | Q13509 | 8/20 | 0.65 |
| ▸ | TUBB2A | Q13885 | 8/20 | 0.65 |
| ▸ | TUBB8 | Q3ZCM7 | 8/20 | 0.65 |
| ▸ | TUBA3E | Q6PEY2 | 8/20 | 0.65 |
| ▸ | TUBA1A | Q71U36 | 8/20 | 0.65 |
| ▸ | TUBA1C | Q9BQE3 | 8/20 | 0.65 |
| ▸ | TUBB6 | Q9BUF5 | 8/20 | 0.65 |
| ▸ | TUBB2B | Q9BVA1 | 8/20 | 0.65 |
| ▸ | TUBB1 | Q9H4B7 | 8/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPY1R | P25929 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5811107 | 0.83 | TUBB4A (0.69) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5806979 | 0.79 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4403569 | 0.77 | TUBB4A (0.54) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL13684493 | 0.74 | ALDH1A1 (0.75) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4544037 | 0.74 | ALDH1A1 (0.53) | ALDH1A1POLBPKMMEN1NPY1R | |
| SCHEMBL4543289 | 0.71 | MAPT (0.54) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL18092632 | 0.70 | MAPT (0.76) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4405258 | 0.69 | TUBB4A (0.70) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5798554 | 0.68 | TUBB4A (0.74) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4029753 | 0.68 | TUBB4A (0.58) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006041961-A1 | ARYLTHIOINDOLE TUBULIN POLYMERIZATION INHIBITORS AND METHODS OF TREATING OR PREVENTING CANCER USING SAME | GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTHAND HUMAN SERVICES (US) | 2006-04-20 | — | — | WO | disclosed |