Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 18/20 | 0.77 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6356183 | 0.88 | P2RX7 (0.82) | P2RX7TRPA1SIGMAR1IDO1TDO2 | |
| SCHEMBL5801683 | 0.87 | P2RX7 (0.71) | P2RX7IDO1TDO2 | |
| SCHEMBL5814515 | 0.87 | P2RX7 (1.00) | P2RX7TRPA1SIGMAR1IDO1TDO2 | |
| SCHEMBL5802163 | 0.84 | P2RX7 (0.67) | P2RX7IDO1TDO2 | |
| SCHEMBL5815683 | 0.82 | P2RX7 (0.81) | P2RX7IDO1TDO2 | |
| SCHEMBL5813093 | 0.81 | P2RX7 (1.00) | P2RX7TRPA1SIGMAR1IDO1TDO2 | |
| SCHEMBL6356890 | 0.80 | P2RX7 (0.62) | P2RX7TRPA1SIGMAR1 | |
| SCHEMBL5812970 | 0.79 | P2RX7 (0.75) | P2RX7TRPA1SIGMAR1 | |
| SCHEMBL5813903 | 0.78 | P2RX7 (0.67) | P2RX7TRPA1SIGMAR1 | |
| SCHEMBL5815194 | 0.78 | P2RX7 (0.82) | P2RX7TRPA1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060211739-A1 | Use of selective P2X7 receptor antagonists | ABBOTT LABORATORIES | 2006-09-21 | — | — | US | claimed |
| WO-2006086229-A1 | THE USE OF SELECTIVE P2X7 RECEPTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 2006-08-17 | — | — | WO | claimed |
| US-20060211739-A1 | Use of selective P2X7 receptor antagonists | ABBOTT LABORATORIES | 2006-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211739-A1 | Use of selective P2X7 receptor antagonists | P2RX1, P2RX3, P2RX7 | P2RX7 3/4885TRPA1 31/4885SIGMAR1 63/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.