Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 18/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5811825 | 0.82 | CHEK1 (0.61) | CHEK1KCNH2 | |
| SCHEMBL14543510 | 0.74 | CHEK1 (0.48) | CHEK1SRC | |
| SCHEMBL4349145 | 0.73 | CHEK1 (0.69) | CHEK1KCNH2 | |
| SCHEMBL3082677 | 0.67 | CHEK1 (0.69) | CHEK1KCNH2 | |
| SCHEMBL21369984 | 0.67 | IRAK4 (0.68) | — | |
| SCHEMBL5458116 | 0.66 | JAK2 (0.41) | SRC | |
| SCHEMBL3118448 | 0.66 | GABBR2 (0.63) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4564373 | 0.65 | CHEK1 (0.68) | CHEK1KCNH2 | |
| SCHEMBL3121999 | 0.65 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4355486 | 0.64 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556053-A4 | ANTIINFLAMMATION AGENTS | AMGEN INC (US) | 2006-04-19 | — | — | EP | disclosed |
| EP-1556053-A1 | ANTIINFLAMMATION AGENTS | Amgen Inc. (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004041285-A1 | ANTIINFLAMMATION AGENTS | AMGEN INC. (US) | 2004-05-21 | — | — | WO | disclosed |