Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | MAP3K20 | Q9NYL2 | 6/20 | 0.47 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 7/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 7/20 | 0.46 |
| ▸ | CSK | P41240 | 4/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | RAF1 | P04049 | 2/20 | 0.46 |
| ▸ | LYN | P07948 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.46 |
| ▸ | ABL2 | P42684 | 2/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5812553 | 0.92 | CHRM1 (0.53) | FGFR1FGFR2FGFR3KDRMAP3K20 | |
| SCHEMBL5819020 | 0.91 | MAP3K20 (0.59) | MAP3K20DDR1MAPK14MAP3K7MAP4K2 | |
| SCHEMBL5821664 | 0.86 | FGFR1 (0.48) | FGFR1FGFR2FGFR3KDRMAP4K2 | |
| SCHEMBL5816678 | 0.85 | FGFR1 (0.53) | FGFR1FGFR2FGFR3KDRMAP3K20 | |
| SCHEMBL5813206 | 0.84 | MAPK14 (0.59) | MAP3K20DDR1MAPK14MAP3K7MAP4K2 | |
| SCHEMBL5820505 | 0.84 | MAPK14 (0.48) | FGFR1FGFR2FGFR3KDRMAP3K20 | |
| SCHEMBL5823136 | 0.84 | FGFR1 (0.57) | FGFR1FGFR2FGFR3KDRMAP3K20 | |
| SCHEMBL5819541 | 0.83 | KDR (0.54) | FGFR1FGFR2FGFR3KDRMAP3K20 | |
| SCHEMBL5817149 | 0.82 | FGFR1 (0.52) | FGFR1FGFR2FGFR3KDRMAPT | |
| SCHEMBL5816340 | 0.82 | FGFR1 (0.53) | FGFR1FGFR2FGFR3KDRMAP3K20 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006124731-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-11-23 | — | — | WO | claimed |
| WO-2006124731-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-11-23 | — | — | WO | disclosed |