Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.48 |
| ▸ | KDR | P35968 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5812553 | 0.93 | CHRM1 (0.53) | FGFR1FGFR2FGFR3KDRMAPT | |
| SCHEMBL5817149 | 0.92 | FGFR1 (0.52) | FGFR1FGFR2FGFR3KDRMAPT | |
| SCHEMBL5819748 | 0.91 | BRAF (0.48) | FGFR1FGFR2FGFR3KDRMAPT | |
| SCHEMBL5812490 | 0.86 | FGFR1 (0.48) | FGFR1FGFR2FGFR3KDRMAPT | |
| SCHEMBL5816678 | 0.85 | FGFR1 (0.53) | FGFR1FGFR2FGFR3KDRMAPT | |
| SCHEMBL5820505 | 0.84 | MAPK14 (0.48) | FGFR1FGFR2FGFR3KDRMAPT | |
| SCHEMBL5823136 | 0.84 | FGFR1 (0.57) | FGFR1FGFR2FGFR3KDRMAPT | |
| SCHEMBL5819541 | 0.83 | KDR (0.54) | FGFR1FGFR2FGFR3KDRMAPT | |
| SCHEMBL5819123 | 0.82 | FGFR1 (0.54) | FGFR1FGFR2FGFR3KDRMAPT | |
| SCHEMBL5816340 | 0.82 | FGFR1 (0.53) | FGFR1FGFR2FGFR3KDRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006124731-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-11-23 | — | — | WO | claimed |
| WO-2006124731-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-11-23 | — | — | WO | disclosed |