Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 9/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5804817 | 0.79 | NTRK1 (0.59) | NTRK1ALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL5801916 | 0.78 | NTRK1 (0.58) | NTRK1ALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL5804272 | 0.78 | NTRK1 (0.62) | NTRK1ALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL5813421 | 0.76 | NTRK1 (0.55) | NTRK1ALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL5804854 | 0.76 | NTRK1 (0.54) | NTRK1ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL5820018 | 0.76 | NTRK1 (0.54) | NTRK1ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL16595137 | 0.75 | NTRK1 (1.00) | NTRK1ALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL5815917 | 0.75 | NTRK1 (0.65) | NTRK1ALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL8252821 | 0.74 | NTRK1 (0.60) | NTRK1ALDH1A1LMNAGAAMEN1 | |
| SCHEMBL5814366 | 0.74 | NTRK1 (0.57) | NTRK1ALDH1A1MAPTKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006085815-A1 | THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2006-08-17 | — | — | WO | disclosed |