Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 9/20 | 0.62 |
| ▸ | FBP1 | P09467 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | ACP1 | P24666 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5815111 | 0.82 | MALT1 (0.41) | NTRK1FBP1KITALDH1A1KDM4E | |
| SCHEMBL5813841 | 0.79 | NTRK1 (0.60) | NTRK1ALDH1A1KDM4EPOLBGAA | |
| SCHEMBL16595137 | 0.79 | NTRK1 (1.00) | NTRK1ALDH1A1KDM4EPOLBGAA | |
| SCHEMBL5804817 | 0.78 | NTRK1 (0.59) | NTRK1ALDH1A1KDM4EPOLBGAA | |
| SCHEMBL5815917 | 0.78 | NTRK1 (0.65) | NTRK1ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL14148480 | 0.78 | KDR (0.44) | FBP1KITALDH1A1KDM4EMAPT | |
| SCHEMBL5813435 | 0.78 | NTRK1 (0.58) | NTRK1ALDH1A1KDM4EPOLBGAA | |
| SCHEMBL5801916 | 0.78 | NTRK1 (0.58) | NTRK1ALDH1A1KDM4EPOLBGAA | |
| SCHEMBL5814366 | 0.77 | NTRK1 (0.57) | NTRK1FBP1ALDH1A1KDM4EPOLB | |
| SCHEMBL5804820 | 0.76 | NTRK1 (0.58) | NTRK1ALDH1A1KDM4EPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006085815-A1 | THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2006-08-17 | — | — | WO | disclosed |
| WO-2006085815-A1 | THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2006-08-17 | — | — | WO | disclosed |