Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 8/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 2/20 | 0.45 |
| ▸ | FLT4 | P35916 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TASP1 | Q9H6P5 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8259565 | 0.86 | KDM4E (0.48) | NTRK1KDM4EGAAMAPTPTGS1 | |
| SCHEMBL8260616 | 0.86 | KDM4E (0.48) | NTRK1KDM4EGAAMAPTPTGS1 | |
| SCHEMBL8252821 | 0.85 | NTRK1 (0.60) | NTRK1GAAPTGS2LMNAALDH1A1 | |
| SCHEMBL8260573 | 0.85 | CYP2C9 (0.47) | NTRK1KDM4EGAAMAPTPTGS1 | |
| SCHEMBL5819206 | 0.83 | ALDH1A1 (0.49) | NTRK1KDM4EGAAMAPTPTGS1 | |
| SCHEMBL8260918 | 0.83 | KDM4E (0.45) | NTRK1KDM4EGAAMAPTPTGDR2 | |
| SCHEMBL5819647 | 0.83 | KDM4E (0.45) | NTRK1KDM4EGAAMAPTPTGDR2 | |
| SCHEMBL5820018 | 0.82 | NTRK1 (0.54) | NTRK1KDM4EGAAMAPTPTGDR2 | |
| SCHEMBL5819644 | 0.82 | KDM4E (0.44) | NTRK1KDM4EGAAMAPTPTGDR2 | |
| SCHEMBL5819740 | 0.81 | KDM4E (0.43) | NTRK1KDM4EGAAMAPTPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006085815-A1 | THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2006-08-17 | — | — | WO | disclosed |
| WO-2006085815-A1 | THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2006-08-17 | — | — | WO | disclosed |