Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | HTT | P42858 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5809245 | 0.89 | KMT2A (0.57) | KDM4EALDH1A1MAPTKMT2AHTT | |
| SCHEMBL5814381 | 0.88 | ALDH1A1 (0.54) | KDM4EALDH1A1GAAMAPTKMT2A | |
| SCHEMBL5809466 | 0.88 | ALDH1A1 (0.54) | KDM4EALDH1A1GAAMAPTKMT2A | |
| SCHEMBL5814909 | 0.87 | KDM4E (0.55) | KDM4EALDH1A1GAAMAPTKMT2A | |
| SCHEMBL5812782 | 0.87 | KDM4E (0.55) | KDM4EALDH1A1GAAMAPTKMT2A | |
| SCHEMBL21436024 | 0.84 | KMT2A (0.60) | KDM4EALDH1A1GAAMAPTKMT2A | |
| SCHEMBL5809168 | 0.84 | KMT2A (0.60) | KDM4EALDH1A1GAAMAPTKMT2A | |
| SCHEMBL5809172 | 0.84 | KMT2A (0.60) | KDM4EALDH1A1GAAMAPTKMT2A | |
| SCHEMBL29490358 | 0.84 | KMT2A (0.60) | KDM4EALDH1A1GAAMAPTKMT2A | |
| SCHEMBL5809443 | 0.78 | MAPT (0.55) | KDM4EALDH1A1MAPTKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006136008-A1 | SALICYLIC ACID HYDRAZONES AS INHIBITORS OF THE ERK MAPKINASE PATHWAY AND FOR THE TREATMENT OF CANCER | UNIVERSITY HEALTH NETWORK (CA) | 2006-12-28 | — | — | WO | disclosed |