Carbamic Acid

Carbamic Acid

SCHEMBL5813768

NC(=O)O.c1ccc2c(c1)CCCOO2

nearest known ligand 0.38

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Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CTNNB1 P35222 1/20 0.38
WNT3A P56704 1/20 0.38
PARP1 P09874 1/20 0.36
CYP1A2 P05177 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
CAMK2A Q9UQM7 1/20 0.35
NOTUM Q6P988 3/20 0.35
TSHR P16473 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.33
TRPM8 Q7Z2W7 1/20 0.33
ALDH1A1 P00352 1/20 0.32
NISCH Q9Y2I1 1/20 0.32
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA9 Q16790 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Carbamic Acid SCHEMBL8524027 0.91 PARP1 (0.39) PARP1CYP2C19NOTUMTSHRSMN1; SMN2
SCHEMBL448796 0.88 TSHR (0.44) CTNNB1WNT3ATSHRSMN1; SMN2CA12
SCHEMBL29631558 0.88 TSHR (0.44) CTNNB1WNT3ATSHRSMN1; SMN2CA12
SCHEMBL1172393 0.88 TSHR (0.44) CTNNB1WNT3ATSHRSMN1; SMN2CA12
SCHEMBL3950945 0.82 TSHR (0.48) TSHRSMN1; SMN2
SCHEMBL3952970 0.80 TSHR (0.46) TSHRSMN1; SMN2
SCHEMBL29788643 0.80 MAOA (0.41) TSHRSMN1; SMN2NISCHCA12CA1
SCHEMBL29788642 0.80 MAOA (0.41) TSHRSMN1; SMN2NISCHCA12CA1
SCHEMBL895328 0.80 MAOA (0.41) TSHRSMN1; SMN2NISCHCA12CA1
SCHEMBL107468 0.80 MAOA (0.41) TSHRSMN1; SMN2NISCHCA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006060082-A1 TRICYCLIC COMPOUNDS, PREPARATION THEREOF AND USE THEREOF AS CHOLINESTERASE ACTIVITY INHIBITORS THE GOVERNMENT OF THE U.S.A. as represented by THE SEC., DEPT. OF HEALTH & HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH (US) 2006-06-08 WO disclosed