Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.46 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.40 |
| ▸ | GNRHR | P30968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5578618 | 0.97 | SIGMAR1 (0.46) | SIGMAR1SLC18A3DRD2AVPR2 | |
| SCHEMBL5578571 | 0.87 | NOTUM (0.43) | GNRHR | |
| SCHEMBL5578889 | 0.87 | SIGMAR1 (0.43) | SIGMAR1DRD2 | |
| SCHEMBL5616199 | 0.87 | SIGMAR1 (0.43) | SIGMAR1SLC18A3DRD2 | |
| SCHEMBL5578880 | 0.84 | KDM2B (0.42) | — | |
| SCHEMBL5578766 | 0.84 | HDAC1 (0.38) | SIGMAR1SLC18A3GNRHR | |
| SCHEMBL14366293 | 0.83 | OPRM1 (0.45) | SIGMAR1 | |
| SCHEMBL5578753 | 0.83 | HDAC1 (0.47) | SIGMAR1 | |
| SCHEMBL5616027 | 0.81 | SIGMAR1 (0.43) | SIGMAR1SLC18A3LMNA | |
| SCHEMBL5578687 | 0.80 | KMT2A (0.48) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | disclosed |