Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | HTR1F | P30939 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR1E | P28566 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5811804 | 0.83 | TLR7 (0.43) | LMNANPSR1GAARAB9AALDH1A1 | |
| SCHEMBL5578091 | 0.82 | ABL1 (0.44) | LMNANPSR1GAACYP1A2CYP3A4 | |
| SCHEMBL5814198 | 0.81 | SCN8A (0.40) | LMNANPSR1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL5105859 | 0.78 | CCNA2 (0.38) | CDK2CCNA2HTR1FCHRM5DRD5 | |
| SCHEMBL5578113 | 0.76 | MEN1 (0.43) | LMNANPSR1GAACYP1A2CYP3A4 | |
| SCHEMBL14511716 | 0.76 | KCNMA1 (0.48) | LMNAHPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8305475 | 0.76 | MAPT (0.53) | LMNANPSR1GAACYP1A2CYP3A4 | |
| SCHEMBL5102502 | 0.75 | HTR1F (0.43) | CYP1A2CYP2C19CYP2C9CDK2CCNA2 | |
| SCHEMBL5813580 | 0.75 | CSNK1D (0.35) | GAASMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL5578253 | 0.75 | MEN1 (0.40) | LMNANPSR1GAACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006070202-A1 | PYRAZOLE DERIVATIVES HAVING KINASE MODULATING ACTIVITY | ASTEX THERAPEUTICS LIMITED (GB) | 2006-07-06 | — | — | WO | disclosed |