Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | YAP1 | P46937 | 1/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5781047 | 0.86 | BTK (0.48) | BTKGPR119PDE4BKCNH2SCN3A | |
| SCHEMBL5777492 | 0.83 | ADAM17 (0.48) | BTKGPR119PDE4BADAM17 | |
| SCHEMBL6233354 | 0.83 | TACR1 (0.43) | BTKGPR119PDE4BTACR1YAP1 | |
| SCHEMBL6235841 | 0.81 | REN (0.45) | BTKGPR119PDE4BTACR1ADAM17 | |
| SCHEMBL6236741 | 0.79 | BTK (0.47) | BTKGPR119KCNH2SCN3A | |
| SCHEMBL3069362 | 0.77 | PDE4B (0.49) | GPR119PDE4B | |
| SCHEMBL4603467 | 0.77 | PDE4B (0.49) | GPR119PDE4B | |
| SCHEMBL3073170 | 0.76 | PDE4B (0.47) | BTKGPR119PDE4BTACR1 | |
| SCHEMBL5778929 | 0.76 | PDE4B (0.48) | GPR119PDE4B | |
| SCHEMBL3059539 | 0.76 | PDE4B (0.52) | GPR119PDE4BTACR1YAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615890-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION | WARNER-LAMBERT COMPANY (US) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004089903-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION | WARNER-LAMBERT COMPANY LLC (US) | 2004-10-21 | — | — | WO | disclosed |