Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM1A | O60341 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5812806 | 1.00 | POLB (0.56) | POLBGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL5815125 | 0.88 | ALDH1A1 (0.50) | POLBRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL5809769 | 0.85 | NPC1 (0.61) | RAB9ANPC1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL5809674 | 0.77 | NPC1 (0.50) | POLBGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL5809953 | 0.77 | NPC1 (0.50) | POLBGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1913833 | 0.77 | KDM4E (0.52) | POLBGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL15882846 | 0.76 | MEN1 (0.55) | POLBGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL12746361 | 0.75 | KDM1A (0.81) | POLBGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL5809466 | 0.75 | ALDH1A1 (0.54) | GAARAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL5814381 | 0.75 | ALDH1A1 (0.54) | GAARAB9ANPC1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006136008-A1 | SALICYLIC ACID HYDRAZONES AS INHIBITORS OF THE ERK MAPKINASE PATHWAY AND FOR THE TREATMENT OF CANCER | UNIVERSITY HEALTH NETWORK (CA) | 2006-12-28 | — | — | WO | claimed |
| WO-2006136008-A1 | SALICYLIC ACID HYDRAZONES AS INHIBITORS OF THE ERK MAPKINASE PATHWAY AND FOR THE TREATMENT OF CANCER | UNIVERSITY HEALTH NETWORK (CA) | 2006-12-28 | — | — | WO | disclosed |