Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 2/20 | 0.47 |
| ▸ | ASF1A | Q9Y294 | 1/20 | 0.47 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5809224 | 0.85 | NPC1 (0.59) | NPC1RAB9AL3MBTL1HTTPAX8 | |
| SCHEMBL5814788 | 0.85 | POLB (0.56) | NPC1RAB9AHTTKMT2AMEN1 | |
| SCHEMBL5812806 | 0.85 | POLB (0.56) | NPC1RAB9AHTTKMT2AMEN1 | |
| SCHEMBL5809953 | 0.84 | NPC1 (0.50) | NPC1RAB9AL3MBTL1HTTKMT2A | |
| SCHEMBL5809674 | 0.84 | NPC1 (0.50) | NPC1RAB9AL3MBTL1HTTKMT2A | |
| SCHEMBL5815125 | 0.84 | ALDH1A1 (0.50) | NPC1RAB9AHTTKMT2AMEN1 | |
| SCHEMBL5809442 | 0.83 | L3MBTL1 (0.50) | NPC1RAB9AL3MBTL1HTTPAX8 | |
| SCHEMBL5809458 | 0.83 | L3MBTL1 (0.50) | NPC1RAB9AL3MBTL1HTTPAX8 | |
| SCHEMBL2987972 | 0.82 | MAPT (0.59) | NPC1RAB9AL3MBTL1HTTKMT2A | |
| Salinazid SCHEMBL1173696 | 0.76 | NPC1 (1.00) | NPC1RAB9AL3MBTL1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006136008-A1 | SALICYLIC ACID HYDRAZONES AS INHIBITORS OF THE ERK MAPKINASE PATHWAY AND FOR THE TREATMENT OF CANCER | UNIVERSITY HEALTH NETWORK (CA) | 2006-12-28 | — | — | WO | disclosed |