Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K2 | Q12851 | 14/20 | 0.50 |
| ▸ | TNK2 | Q07912 | 13/20 | 0.50 |
| ▸ | ABL1 | P00519 | 6/20 | 0.50 |
| ▸ | BMX | P51813 | 3/20 | 0.50 |
| ▸ | KDR | P35968 | 3/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FES | P07332 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.50 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.50 |
| ▸ | TEK | Q02763 | 1/20 | 0.50 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.50 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5816482 | 0.93 | ABL1 (0.54) | MAP4K2TNK2ABL1BMXKDR | |
| SCHEMBL5818951 | 0.87 | MAP4K2 (0.52) | MAP4K2TNK2ABL1BMXKDR | |
| SCHEMBL5813589 | 0.85 | TNK2 (0.61) | MAP4K2TNK2ABL1BMXKDR | |
| SCHEMBL5813818 | 0.79 | FGFR1 (0.46) | MAP4K2TNK2ABL1KDRFGFR1 | |
| SCHEMBL5820599 | 0.77 | MAP4K2 (0.67) | MAP4K2TNK2ABL1BMXKDR | |
| SCHEMBL5820613 | 0.77 | TNK2 (0.57) | MAP4K2TNK2ABL1BMXKDR | |
| SCHEMBL5815047 | 0.76 | MAP4K2 (0.61) | MAP4K2TNK2ABL1BMXKDR | |
| SCHEMBL5820634 | 0.76 | MAP4K2 (0.55) | MAP4K2TNK2ABL1BMXKDR | |
| SCHEMBL5814252 | 0.75 | FGFR1 (0.58) | MAP4K2TNK2ABL1BMXKDR | |
| SCHEMBL5819608 | 0.75 | MAP4K2 (0.62) | MAP4K2TNK2ABL1FESSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006124731-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-11-23 | — | — | WO | claimed |