Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 19/20 | 1.00 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5813357 | 0.99 | P2RX7 (0.98) | P2RX7TRPA1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL12878445 | 0.87 | P2RX7 (0.77) | P2RX7TRPA1SIGMAR1 | |
| SCHEMBL6358683 | 0.86 | P2RX7 (0.80) | P2RX7TRPA1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL5815194 | 0.84 | P2RX7 (0.82) | P2RX7TRPA1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL5814515 | 0.84 | P2RX7 (1.00) | P2RX7TRPA1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL12878441 | 0.82 | P2RX7 (0.69) | P2RX7TRPA1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL5810375 | 0.82 | P2RX7 (0.70) | P2RX7TRPA1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL5917673 | 0.82 | P2RX7 (0.69) | P2RX7TRPA1SIGMAR1 | |
| SCHEMBL5802261 | 0.80 | P2RX7 (1.00) | P2RX7TRPA1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL5917667 | 0.80 | P2RX7 (0.75) | P2RX7TRPA1SIGMAR1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060211739-A1 | Use of selective P2X7 receptor antagonists | ABBOTT LABORATORIES | 2006-09-21 | — | — | US | disclosed |
| WO-2006086229-A1 | THE USE OF SELECTIVE P2X7 RECEPTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 2006-08-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211739-A1 | Use of selective P2X7 receptor antagonists | P2RX1, P2RX3, P2RX7 | P2RX7 3/4885TRPA1 31/4885SIGMAR1 63/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.