Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 5/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.41 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | RAF1 | P04049 | 6/20 | 0.38 |
| ▸ | BRAF | P15056 | 5/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5817693 | 0.91 | MAP4K2 (0.50) | FGFR1FGFR2FGFR3KDRMAP4K2 | |
| SCHEMBL5819117 | 0.90 | FGFR1 (0.47) | FGFR1FGFR2FGFR3KDRMAP4K2 | |
| SCHEMBL5814241 | 0.88 | FGFR1 (0.47) | FGFR1FGFR2FGFR3KDRMAP4K2 | |
| SCHEMBL5819453 | 0.84 | KDR (0.51) | FGFR1FGFR2FGFR3KDRMAP4K2 | |
| SCHEMBL5819808 | 0.84 | MAP3K20 (0.47) | FGFR1FGFR2FGFR3KDRMAP4K2 | |
| SCHEMBL5819066 | 0.82 | KDR (0.51) | FGFR1FGFR2FGFR3KDRMAP3K20 | |
| SCHEMBL5812530 | 0.80 | MAP4K2 (0.60) | FGFR1FGFR3KDRMAP4K2TNK2 | |
| SCHEMBL5813818 | 0.79 | FGFR1 (0.46) | FGFR1FGFR2FGFR3KDRMAP4K2 | |
| SCHEMBL5823136 | 0.79 | FGFR1 (0.57) | FGFR1FGFR2FGFR3KDRMAP4K2 | |
| SCHEMBL5817149 | 0.79 | FGFR1 (0.52) | FGFR1FGFR2FGFR3KDRNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006124731-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-11-23 | — | — | WO | claimed |
| WO-2006124731-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-11-23 | — | — | WO | disclosed |