Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 3/20 | 0.41 |
| ▸ | USP1 | O94782 | 1/20 | 0.41 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5124391 | 0.95 | MEN1 (0.45) | HIF1AMEN1KMT2ANPC1PDE5A | |
| SCHEMBL5119043 | 0.90 | USP1 (0.50) | HIF1AMEN1KMT2ANPC1PDE5A | |
| SCHEMBL7504877 | 0.89 | MAPT (0.41) | MEN1KMT2APDE5AUSP1WDR48 | |
| SCHEMBL5128120 | 0.88 | MEN1 (0.45) | HIF1AMEN1KMT2ANPC1PDE5A | |
| SCHEMBL7509495 | 0.87 | USP1 (0.46) | HIF1AMEN1KMT2ANPC1PDE5A | |
| SCHEMBL7513993 | 0.86 | PDE5A (0.41) | HIF1AMEN1KMT2ANPC1PDE5A | |
| SCHEMBL7610471 | 0.86 | METAP1 (0.47) | HIF1AMEN1KMT2ANPC1PDE5A | |
| SCHEMBL5118399 | 0.86 | ICAM1 (0.46) | HIF1AMEN1KMT2ANPC1PDE5A | |
| SCHEMBL7507644 | 0.84 | MAPT (0.56) | HIF1AMEN1KMT2APDE5AMAPT | |
| SCHEMBL5115725 | 0.84 | KMT2A (0.48) | HIF1AMEN1KMT2ANPC1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685136-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005047292-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 2005-05-26 | — | — | WO | disclosed |