Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | USP1 | O94782 | 1/20 | 0.38 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7519412 | 0.95 | PDE5A (0.46) | PDE5ANPC1MEN1KMT2AUSP1 | |
| SCHEMBL5128646 | 0.95 | MEN1 (0.42) | PDE5ANPC1MEN1KMT2AUSP1 | |
| SCHEMBL5128928 | 0.90 | USP1 (0.47) | PDE5ANPC1MEN1KMT2AUSP1 | |
| SCHEMBL5813789 | 0.88 | METAP1 (0.40) | PDE5ANPC1KMT2AUSP1WDR48 | |
| SCHEMBL7611837 | 0.87 | METAP1 (0.43) | NPC1KMT2AHIF1AMAPTALDH1A1 | |
| SCHEMBL5815313 | 0.86 | HIF1A (0.41) | PDE5ANPC1MEN1KMT2AUSP1 | |
| SCHEMBL5115046 | 0.85 | NPC1 (0.44) | PDE5ANPC1MEN1KMT2AUSP1 | |
| SCHEMBL5128405 | 0.85 | MAPT (0.41) | PDE5AMEN1KMT2AUSP1WDR48 | |
| SCHEMBL5128120 | 0.84 | MEN1 (0.45) | PDE5ANPC1MEN1KMT2AUSP1 | |
| SCHEMBL5126388 | 0.83 | L3MBTL1 (0.43) | PDE5ANPC1KMT2AUSP1WDR48 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920431-A1 | THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998006722-A1 | THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 1998-02-19 | — | — | WO | disclosed |