Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 17/20 | 0.53 |
| ▸ | CDK2AP1 | O14519 | 7/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702699 | 0.88 | CHEK1 (0.54) | CHEK1CDK2AP1JAK3BTKHRH2 | |
| SCHEMBL4216335 | 0.85 | CHEK1 (0.72) | CHEK1CDK2AP1 | |
| SCHEMBL4706485 | 0.85 | CHEK1 (0.72) | CHEK1CDK2AP1 | |
| SCHEMBL4208380 | 0.85 | CHEK1 (0.72) | CHEK1CDK2AP1 | |
| SCHEMBL4206504 | 0.84 | CHEK1 (0.60) | CHEK1CDK2AP1JAK3BTK | |
| SCHEMBL4706488 | 0.83 | CHEK1 (0.56) | CHEK1CDK2AP1 | |
| Trifluoroacetic Acid SCHEMBL4216009 | 0.81 | CHEK1 (0.67) | CHEK1CDK2AP1 | |
| Trifluoroacetic Acid SCHEMBL4211656 | 0.81 | CHEK1 (0.67) | CHEK1CDK2AP1 | |
| SCHEMBL4214970 | 0.81 | CHEK1 (0.57) | CHEK1CDK2AP1JAK3BTK | |
| SCHEMBL5437284 | 0.81 | CHEK1 (0.73) | CHEK1CDK2AP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660474-A1 | SUBSTITUTED THIOPHENES AND USES THEREOF | AstraZeneca AB (SE) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005016909-A1 | SUBSTITUTED THIOPHENES AND USES THEREOF | ASTRAZENECA AB (SE) | 2005-02-24 | — | — | WO | disclosed |