Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | XIAP | P98170 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5815983 | 0.72 | CYP1A2 (0.43) | ALDH1A1GAAPOLBCYP1A2HSD17B10 | |
| SCHEMBL27684678 | 0.72 | ALDH1A1 (0.41) | ALDH1A1GAAPOLBCYP1A2HSD17B10 | |
| SCHEMBL4141222 | 0.70 | MAPT (0.40) | BTKALDH1A1HSD17B10MAPK1MAPT | |
| SCHEMBL1721531 | 0.70 | CYP1A2 (0.46) | ALDH1A1GAAPOLBCYP1A2HSD17B10 | |
| SCHEMBL21916304 | 0.68 | MME (0.41) | ALDH1A1GAAPOLBCYP1A2MAPT | |
| SCHEMBL8557878 | 0.68 | ALDH1A1 (0.63) | ALDH1A1GAAPOLBCYP1A2HSD17B10 | |
| SCHEMBL4125428 | 0.67 | MAPT (0.38) | ALDH1A1GAAMAPTLMNAHIF1A | |
| SCHEMBL544732 | 0.67 | ALDH1A1 (0.62) | ALDH1A1GAAPOLBCYP1A2HSD17B10 | |
| SCHEMBL544015 | 0.67 | ALDH1A1 (0.77) | ALDH1A1POLBCYP1A2HSD17B10MAPK1 | |
| SCHEMBL543809 | 0.67 | NTRK1 (0.51) | ALDH1A1GAAPOLBCYP1A2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006085815-A1 | THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2006-08-17 | — | — | WO | disclosed |