SCHEMBL5816620

SCHEMBL5816620

CC(=O)NCCCOc1ccc(C2CCCCN2CCNc2ccc(Cl)c(C(F)(F)F)c2)c(C)c1C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.39
EPHX2 P34913 2/20 0.38
ALOX5 P09917 1/20 0.38
NOTUM Q6P988 1/20 0.38
MAPT P10636 4/20 0.37
ALDH1A1 P00352 3/20 0.37
LMNA P02545 3/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
RAF1 P04049 2/20 0.37
MAPK14 Q16539 2/20 0.37
HTT P42858 3/20 0.37
MAPK1 P28482 2/20 0.37
ATM Q13315 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
NPSR1 Q6W5P4 2/20 0.36
BRAF P15056 1/20 0.36
USP2 O75604 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5796981 0.88 NOTUM (0.38) NOTUMMAPTALDH1A1LMNASMN1; SMN2
SCHEMBL5809564 0.87 NOTUM (0.39) NOTUMMAPTALDH1A1LMNASMN1; SMN2
SCHEMBL5795788 0.87 UTS2R (0.40) EPHX2NOTUMMAPTALDH1A1LMNA
SCHEMBL5795841 0.86 UTS2R (0.44) EPHX2NOTUMMAPTALDH1A1LMNA
SCHEMBL5796876 0.85 MAPT (0.42) NOTUMMAPTALDH1A1LMNASMN1; SMN2
SCHEMBL5794176 0.82 NTRK1 (0.37) MAPTALDH1A1LMNASMN1; SMN2RAF1
SCHEMBL5794210 0.81 ALDH1A1 (0.37) TSHRMAPTALDH1A1LMNASMN1; SMN2
SCHEMBL5805738 0.81 SMN1; SMN2 (0.39) TSHREPHX2MAPTALDH1A1LMNA
SCHEMBL5794482 0.76 MAPT (0.56) MAPTALDH1A1LMNASMN1; SMN2HTT
SCHEMBL5794585 0.74 SMN1; SMN2 (0.44) MAPTALDH1A1LMNASMN1; SMN2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006015279-A1 HETEROCYCLIC DIAMINE COMPOUNDS AS LIGANDS OF THE MELANIN CONCENTRATING HORMONE RECEPTOR USEFUL FOR THE TREATMENT OF OBESITY, DIABETES, EATING AND SEXUAL DISORDERS NEUROGEN CORPORATION (US) 2006-02-09 WO claimed