Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.56 |
| ▸ | LMNA | P02545 | 9/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5796637 | 0.87 | LMNA (0.59) | MAPTLMNAALDH1A1HTTMAPK1 | |
| SCHEMBL5796876 | 0.85 | MAPT (0.42) | MAPTLMNAALDH1A1HTTMAPK1 | |
| SCHEMBL5820332 | 0.80 | LMNA (0.54) | MAPTLMNAALDH1A1HTTMAPK1 | |
| SCHEMBL5793624 | 0.78 | HCRTR1 (0.40) | KDM4EHCRTR1 | |
| SCHEMBL5809564 | 0.76 | NOTUM (0.39) | MAPTLMNAALDH1A1HTTMAPK1 | |
| SCHEMBL5816620 | 0.76 | TSHR (0.39) | MAPTLMNAALDH1A1HTTMAPK1 | |
| SCHEMBL5796981 | 0.76 | NOTUM (0.38) | MAPTLMNAALDH1A1HTTMAPK1 | |
| SCHEMBL5795178 | 0.75 | SMN1; SMN2 (0.54) | MAPTLMNAALDH1A1HTTL3MBTL1 | |
| SCHEMBL5805401 | 0.75 | NCOA1 (0.51) | MAPTLMNAALDH1A1HTTMAPK1 | |
| SCHEMBL5808924 | 0.75 | LMNA (0.47) | MAPTLMNAALDH1A1HTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006015279-A1 | HETEROCYCLIC DIAMINE COMPOUNDS AS LIGANDS OF THE MELANIN CONCENTRATING HORMONE RECEPTOR USEFUL FOR THE TREATMENT OF OBESITY, DIABETES, EATING AND SEXUAL DISORDERS | NEUROGEN CORPORATION (US) | 2006-02-09 | — | — | WO | claimed |