Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 5/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.73 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | PTAFR | P25105 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11793386 | 0.86 | OPRK1 (0.57) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| Estazolam SCHEMBL28766 | 0.84 | OPRK1 (1.00) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| Estazolam SCHEMBL29357458 | 0.84 | OPRK1 (1.00) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL11108528 | 0.82 | OPRK1 (0.74) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL6060113 | 0.81 | OPRK1 (0.72) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL7328162 | 0.80 | OPRK1 (0.71) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL11016086 | 0.80 | OPRK1 (0.70) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL11199716 | 0.79 | OPRK1 (0.46) | OPRK1PDE4DPTAFR | |
| SCHEMBL11714001 | 0.78 | OPRK1 (0.65) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL11116626 | 0.78 | OPRK1 (0.67) | OPRK1PDE4DGABRA1GABRA5GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0104053-A1 | Benzodiazepines for treating panic disorders | THE UPJOHN COMPANY (US) | 1984-03-28 | — | — | EP | claimed |
| WO-2006036928-A2 | INHIBITORS OF MATRIX METALLOPROTEINASES TO TREAT NEUROLOGICAL DISORDERS | WAYNE STATE UNIVERSITY (US) | 2006-04-06 | — | — | WO | disclosed |
| EP-0139460-A2 | Benzodiazepines and their therapeutic use | THE UPJOHN COMPANY (US) | 1985-05-02 | — | — | EP | disclosed |
| EP-0104053-A1 | Benzodiazepines for treating panic disorders | THE UPJOHN COMPANY (US) | 1984-03-28 | — | — | EP | disclosed |