Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.72 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.72 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.50 |
| ▸ | CCKBR | P32239 | 2/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | PTAFR | P25105 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11838406 | 0.86 | OPRK1 (0.55) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL11838409 | 0.86 | OPRK1 (0.55) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| Estazolam SCHEMBL29357458 | 0.84 | OPRK1 (1.00) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| Estazolam SCHEMBL28766 | 0.84 | OPRK1 (1.00) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL11108528 | 0.84 | OPRK1 (0.74) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL11883943 | 0.83 | OPRK1 (0.58) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL7328162 | 0.82 | OPRK1 (0.71) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL11655855 | 0.82 | OPRK1 (0.51) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL5816680 | 0.81 | OPRK1 (0.73) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL14215472 | 0.80 | OPRK1 (0.49) | OPRK1PDE4DGABRA1GABRA5GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3987052-A | SEDATIVES, TRANQUILIZERS, MUSCLE RELAXANTS | THE UPJOHN COMPANY (US) | 1976-10-19 | — | — | US | claimed |
| EP-4126869-B1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAMS | HOFFMANN LA ROCHE (CH) | 2024-06-05 | — | — | EP | disclosed |
| EP-4139310-B1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | HOFFMANN LA ROCHE (CH) | 2024-03-27 | — | — | EP | disclosed |
| US-7074388-B2 | Water stabilized medicinal aerosol formulation | KOS LIFE SCIENCE, INC. (US) | 2006-07-11 | — | — | US | disclosed |
| EP-1569617-A1 | WATER STABILIZED MEDICINAL AEROSOL FORMULATION RELATED APPLICATIONS | Kos Life Sciences, Inc. (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004022035-A1 | WATER STABILIZED MEDICINAL AEROSOL FORMULATION RELATED APPLICATIONS | KOS PHARMACEUTICALS, INC. (US) | 2004-03-18 | — | — | WO | disclosed |
| US-20030091512-A1 | Water stabilized medicinal aerosol formulation | KOS LIFE SCIENCES, INC. | 2003-05-15 | — | — | US | disclosed |
| EP-1301173-A1 | A MEDICINAL AEROSOL FORMULATION | Aeropharm Technology Incorporated (US) | 2003-04-16 | — | — | EP | disclosed |
| US-6458338-B1 | Amino acid stabilized medicinal aerosol formulations | AEROPHARM TECHNOLOGY INCORPORATED | 2002-10-01 | — | — | US | disclosed |
| WO-2002015883-A1 | A METHOD OF STABILIZING A DRY POWDER PHARMACEUTICAL FORMULATION | AEROPHARM TECHNOLOGY INCORPORATED (US) | 2002-02-28 | — | — | WO | disclosed |
| US-4180668-A | Piperidino-4H-s-triazolo[4,3-a][1,4]benzodiazepines | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4000289-A | 6-PHENYL-4H-S-TRIAZOLO(4,3-A)(1,4)BENZODIAZEPINES | THE UPJOHN COMPANY (US) | 1976-12-28 | — | — | US | disclosed |
| US-3993660-A | 2-[3-(Phthalimidomethyl)-5-methyl-4H-1,2,4-triazol-4-yl]benzophenones | THE UPJOHN COMPANY (US) | 1976-11-23 | — | — | US | disclosed |
| US-3993660-A | 2-[3-(Phthalimidomethyl)-5-methyl-4H-1,2,4-triazol-4-yl]benzophenones | THE UPJOHN COMPANY (US) | 1976-11-23 | — | — | US | disclosed |
| US-3987052-A | SEDATIVES, TRANQUILIZERS, MUSCLE RELAXANTS | THE UPJOHN COMPANY (US) | 1976-10-19 | — | — | US | disclosed |
| US-3987052-A | SEDATIVES, TRANQUILIZERS, MUSCLE RELAXANTS | THE UPJOHN COMPANY (US) | 1976-10-19 | — | — | US | disclosed |
| US-3987052-A | SEDATIVES, TRANQUILIZERS, MUSCLE RELAXANTS | THE UPJOHN COMPANY (US) | 1976-10-19 | — | — | US | disclosed |
| US-3886174-A | 1-Substituted-6-phenyl-4H-s-triazolo{8 4,3-a{9 {8 1,4{9 benzodiazepines | UPJOHN CO | 1975-05-27 | — | — | US | disclosed |
| US-3879413-A | Process for the production of 6-phenyl-4-H-s-triazolo {8 4,3-a{9 {8 1,4{9 benzodiazepines | UPJOHN CO | 1975-04-22 | — | — | US | disclosed |
| US-3709899-A | 6-PHENYL-4H-S-TRIAZOLO(4,3-A)(1,4)BENZODIAZEPINES AND THEIR PRODUCTION | UPJOHN CO | 1973-01-09 | — | — | US | disclosed |