Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.59 |
| ▸ | HTR2B | P41595 | 4/20 | 0.56 |
| ▸ | HTR2A | P28223 | 6/20 | 0.54 |
| ▸ | HTR1A | P08908 | 5/20 | 0.54 |
| ▸ | HTR2C | P28335 | 4/20 | 0.54 |
| ▸ | HTR1D | P28221 | 3/20 | 0.54 |
| ▸ | HTR1B | P28222 | 3/20 | 0.54 |
| ▸ | HTR7 | P34969 | 3/20 | 0.54 |
| ▸ | HTR6 | P50406 | 3/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL217937 | 0.85 | GPR84 (0.76) | GPR84HTR2BHTR2AHTR1AHTR2C | |
| Mebufotenin SCHEMBL33563480 | 0.80 | HTR2A (0.54) | GPR84HTR2BHTR2AHTR1AHTR2C | |
| Melatonin SCHEMBL5815299 | 0.76 | MTNR1A (0.78) | HTR2BHTR1AHTR2CCYP2D6CYP1A2 | |
| SCHEMBL5431365 | 0.75 | GPR84 (1.00) | GPR84HTR2BHTR2AHTR1AHTR2C | |
| SCHEMBL16824132 | 0.74 | SLC6A4 (0.71) | GPR84HTR2BHTR2AHTR1AHTR2C | |
| SCHEMBL178561 | 0.73 | GPR84 (0.78) | GPR84HTR2BHTR2AHTR1AHTR2C | |
| SCHEMBL947733 | 0.72 | GPR84 (0.76) | GPR84HTR2BHTR2AHTR1AHTR2C | |
| SCHEMBL1723383 | 0.72 | CYP2D6 (0.77) | GPR84HTR2BHTR2AHTR1AHTR2C | |
| SCHEMBL3976318 | 0.72 | HTR2B (1.00) | GPR84HTR2BHTR2AHTR1AHTR2C | |
| SCHEMBL2125628 | 0.72 | HTR2A (0.68) | GPR84HTR2BHTR2AHTR1AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006086978-A2 | USE OF DEUTERATED N-[2-(5-METHOXY-1H-INDOL-3-YL)-ETHYL]ACETAMIDES AND THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, AND MEDICAMENTS CONTAINING SAID COMPOUNDS | BIRDS PHARMA GMBH BEROLINA INNOVATIVE RESEARCH & DEVELOPMENT SERVICES (DE) | 2006-08-24 | — | — | WO | claimed |