Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 3/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5819870 | 0.90 | MAPK14 (0.36) | PTGDR2BRAFKMOMAPK13RAF1 | |
| SCHEMBL5818348 | 0.85 | MAPK14 (0.36) | PTGDR2MAPK13RAF1MAPK12MAPK11 | |
| SCHEMBL5819125 | 0.83 | CKS1B (0.38) | PTGDR2BRAF | |
| SCHEMBL5819534 | 0.81 | MAPK14 (0.38) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5819457 | 0.80 | EGFR (0.39) | MAPK11MAPK14 | |
| SCHEMBL5818792 | 0.80 | MAPK14 (0.40) | KMOMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5818359 | 0.79 | KCNH2 (0.41) | BRAFKCNH2RAF1MAPK14 | |
| SCHEMBL5819170 | 0.78 | CAMK2D (0.47) | MAPK13RAF1MAPK12MAPK11MAPK14 | |
| SCHEMBL5815121 | 0.77 | BRAF (0.50) | BRAFKCNH2ACHERAF1MAPK14 | |
| SCHEMBL5814145 | 0.75 | PIK3CA (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137658-A1 | NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONGBU HITEK CO., LTD. (KR) | 2006-12-28 | — | — | WO | disclosed |