Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5819634 | 0.89 | KCNH2 (0.48) | KCNH2 | |
| SCHEMBL5819618 | 0.85 | EGFR (0.43) | EGFRRAF1ERBB2SRCKDR | |
| SCHEMBL5818662 | 0.84 | KCNH2 (0.44) | EGFRRAF1ERBB2SRCKDR | |
| SCHEMBL5819631 | 0.84 | EGFR (0.44) | EGFRRAF1ERBB2SRCKDR | |
| SCHEMBL5816216 | 0.84 | EGFR (0.48) | EGFRRAF1ERBB2SRCKDR | |
| SCHEMBL5814016 | 0.83 | EGFR (0.43) | EGFRRAF1ERBB2SRCKDR | |
| SCHEMBL5823310 | 0.80 | ALDH1A1 (0.51) | KCNH2 | |
| SCHEMBL5818972 | 0.80 | EGFR (0.64) | EGFRRAF1ERBB2SRCKDR | |
| SCHEMBL5815611 | 0.80 | KCNH2 (0.54) | EGFRRAF1ERBB2SRCKDR | |
| SCHEMBL5820563 | 0.79 | KMT2A (0.47) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137658-A1 | NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONGBU HITEK CO., LTD. (KR) | 2006-12-28 | — | — | WO | claimed |