SCHEMBL5820563

SCHEMBL5820563

COc1ccc(-c2nc(N3CCNCC3)sc2-c2ccnc([C@@](C)(N)c3ccccc3)n2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.47
KCNH2 Q12809 5/20 0.46
ALDH1A1 P00352 6/20 0.41
HTT P42858 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
CETP P11597 1/20 0.41
USP2 O75604 5/20 0.39
CYP1A2 P05177 5/20 0.39
HIF1A Q16665 5/20 0.39
CASP1 P29466 4/20 0.39
CASP7 P55210 4/20 0.39
CYP3A4 P08684 3/20 0.39
HPGD P15428 3/20 0.39
HSD17B10 Q99714 3/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
MAPK1 P28482 2/20 0.39
HTR1A P08908 1/20 0.38
HTR7 P34969 1/20 0.38
GLA P06280 2/20 0.36
TP53 P04637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5823310 0.91 ALDH1A1 (0.51) KMT2AKCNH2ALDH1A1HTTNPSR1
SCHEMBL5817615 0.90 KCNH2 (0.57) KCNH2
SCHEMBL5820844 0.84 KCNH2 (0.41) KMT2AKCNH2ALDH1A1NPSR1HIF1A
SCHEMBL5823205 0.84 KCNH2 (0.47) KCNH2HTR1AHTR7
SCHEMBL5819634 0.83 KCNH2 (0.48) KCNH2
SCHEMBL5818957 0.82 KCNH2 (0.43) KCNH2CYP1A2HTR1AHTR7CYP2C9
SCHEMBL5820567 0.80 KCNH2 (0.50) KMT2AKCNH2MAPK1IKBKBCHUK
SCHEMBL5819576 0.79 KMT2A (0.53) KMT2AKCNH2ALDH1A1HTTNPSR1
SCHEMBL5818970 0.79 EGFR (0.47) KCNH2
SCHEMBL5816363 0.78 KCNH2 (0.53) KMT2AKCNH2IKBKBCHUK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006137658-A1 NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME DONGBU HITEK CO., LTD. (KR) 2006-12-28 WO claimed
WO-2006137658-A1 NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME DONGBU HITEK CO., LTD. (KR) 2006-12-28 WO disclosed