Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 7/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.43 |
| ▸ | CDK4 | P11802 | 8/20 | 0.42 |
| ▸ | GSK3B | P49841 | 5/20 | 0.42 |
| ▸ | CDK2 | P24941 | 5/20 | 0.42 |
| ▸ | RET | P07949 | 4/20 | 0.40 |
| ▸ | CDK1 | P06493 | 4/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | INSR | P06213 | 2/20 | 0.40 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | PRKACA | P17612 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5819164 | 0.95 | CDK1 (0.46) | MAPK8MAPK9MAPK10CDK4GSK3B | |
| SCHEMBL5819153 | 0.81 | MAPK14 (0.50) | MAPK8MAPK9CDK4GSK3BCDK2 | |
| SCHEMBL5813505 | 0.80 | BRAF (0.52) | MAPK8MAPK9MAPK10CDK4GSK3B | |
| SCHEMBL5813694 | 0.77 | KCNH2 (0.45) | MAPK8MAPK9MAPK10CDK4GSK3B | |
| SCHEMBL5816273 | 0.77 | KCNH2 (0.53) | — | |
| SCHEMBL5819338 | 0.77 | MAPK13 (0.48) | MAPK8MAPK9MAPK10CDK4GSK3B | |
| SCHEMBL5819869 | 0.77 | MAPK13 (0.45) | MAPK8MAPK9GSK3BMAPK13MAPKAPK2 | |
| SCHEMBL5819159 | 0.76 | MAPK13 (0.48) | MAPK8MAPK9MAPK10CDK4GSK3B | |
| SCHEMBL5816324 | 0.76 | BRAF (0.49) | MAPK10CDK4GSK3BCDK2RET | |
| SCHEMBL5818808 | 0.76 | KCNH2 (0.50) | MAPK8MAPK9MAPK10CDK4GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137658-A1 | NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONGBU HITEK CO., LTD. (KR) | 2006-12-28 | — | — | WO | claimed |
| WO-2006137658-A1 | NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONGBU HITEK CO., LTD. (KR) | 2006-12-28 | — | — | WO | disclosed |